Thiyl free radical production with hematoporphyrin derivative, cysteine and light: a spin-trapping study.
نویسنده
چکیده
Hematoporphyrin derivative, used in photodynamic therapy of cancer, was found to generate the cysteinyl free radical as seen by spin-trapping. Oxygen appears to be an absolute requirement for thiyl radical production. Singlet oxygen may be the initiating species since azide inhibits oxygen uptake and radical production. In addition, the hydroxyl radical, or a radical with similar reactivity, is also observed and is proposed as the precursor for thiyl free radical production.
منابع مشابه
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ورودعنوان ژورنال:
- FEBS letters
دوره 177 2 شماره
صفحات -
تاریخ انتشار 1984